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Paul Stamets Stack: Get Started with Stamets Protocol

Paul Stamets, a renowned mycologist, has introduced a unique microdosing protocol called the Stamets Stack. It combines psilocybin-containing mushrooms, Lion’s mane, and niacin to promote neuroregeneration and unlock cognitive benefits.

Here, we will explore the Stamets Stack and the evidence surrounding its potential benefits.

What is a microdosing protocol?

A microdosing protocol is a structured schedule for taking very low doses of psychedelic substances to enhance well-being, creativity, or performance.

These protocols involve consuming sub-perceptual doses, typically one-tenth or one-twentieth of a full dose, to avoid any psychedelic effects. Different protocols exist for beginners and experienced microdosers, incorporating substances like psilocybin, Lion’s Mane, Niacin, or saffron.

Each protocol follows specific guidelines, such as the Fadiman Protocol for beginners or the Stamets Protocol for more advanced users. These protocols help individuals find their optimal dosage and frequency and provide structure for a safe and intentional microdosing practice.

Who is Paul Stamets?

Paul Stamets is a renowned mycologist and advocate of fungi. He has made significant contributions to fields such as bee conservation, environmental cleanup, and sustainable building materials.

With six books to his name, he is an authority on mushrooms and has pioneered methods for using them in oil spill cleanup. Stamets has also delved into the study of psychedelic medicines, particularly the therapeutic potential of psilocybin mushrooms.

His work has earned him recognition, including induction into the National Mycological Society Hall of Fame and a spot on TIME magazine’s “TIME 100” list of influential people. Overall, Stamets continues to inspire advancements in mycology and highlight the diverse benefits of fungi.

Who is Paul Stamets

The Stamets Stack

The Stamets Stack is a microdosing protocol developed by Paul Stamets, a well-known mycologist. It involves combining psilocybin mushrooms, Lion’s mane mushrooms, and niacin (vitamin B3) to enhance cognition and promote neurodegeneration. The combination of these substances in the Stamets Stack is believed to work synergistically to improve brain function.

Lion’s mane mushrooms have neuroprotective properties and have been studied for their positive effects on depression, anxiety and cognitive impairment. Niacin acts as a vasodilator, improving the distribution of the stack’s components in the body and brain.

It’s important to note that this protocol is more intense and suitable for experienced microdosers, and medical advice should be sought. It is recommended not to exceed one month of usage, followed by a reset period.

Lion’s Mane

This non-psychedelic mushroom has been used in traditional Chinese medicine and shows neurogenerative and neuroprotective properties. Lion’s Mane mushroom may improve cognitive impairment and reduce symptoms of depression and anxiety.


Also known as Vitamin B3, niacin plays a vital role in energy production and supports the health of the skin and nervous system. In the stack, niacin acts as a flushing agent, assisting in the delivery of beneficial compounds to the brain. It also promotes neuronal development and serves as an anti-abuse agent.


Found in magic mushrooms, psilocybin is a classic psychedelic that can alter perception, mood, and cognition. Research suggests it may reduce depression and anxiety and stimulate neurogenesis, potentially enhancing intelligence, kindness, and courage.

Paul Stamet’s Microdosing Dosage

The dosage for Paul Stamets’ Microdosing Protocol varies depending on the specific components of the stack. For psilocybin mushrooms, the recommended dosage is 0.1 to 1 gram of Psilocybe cubensis, which constitutes a microdose. Lion’s mane mushrooms should be consumed in a range of 5 to 20 grams. As for Niacin (Vitamin B3), the recommended dosage is 100 to 200 milligrams.

Specifically, according to the Stamets Protocol, for an individual weighing around 70 kilograms, the following dosages are suggested: 0.5 to 1 gram of Psilocybin Truffles, 50 to 200 milligrams of Lion’s Mane Erinacines/Hericinones, and 100 to 200 milligrams of Niacin.

Stamets Protocol specific dosages for a 70-kilogram individual:

  1. Psilocybin Truffles:
    • Dosage: 0.5 to 1 gram
  2. Lion’s Mane Erinacines/Hericinones:
    • Dosage: 50 to 200 milligrams
  3. Niacin:
    • Dosage: 100 to 200 milligrams (build-up, see below)

It is important to note that these dosages may vary based on individual factors, and it is advisable to consult with a healthcare professional or expert before starting any microdosing regimen.

Stamets Protocol Schedule

Stamets Protocol Schedule

The Stamets Protocol involves a four-day microdosing cycle followed by three days of rest. The schedule is as follows:

Week 1:

  • Monday: Microdose Truffles + Lion’s Mane + Niacin
  • Tuesday: Microdose Truffles + Lion’s Mane + Niacin
  • Wednesday: Microdose Truffles + Lion’s Mane + Niacin
  • Thursday: Microdose Truffles + Lion’s Mane + Niacin
  • Friday: Rest (Lion’s Mane)
  • Saturday: Rest (Lion’s Mane)
  • Sunday: Rest (Lion’s Mane)

Week 2:

  • Monday: Microdose Truffles + Lion’s Mane + Niacin
  • Tuesday: Microdose Truffles + Lion’s Mane + Niacin
  • Wednesday: Microdose Truffles + Lion’s Mane + Niacin
  • Thursday: Microdose Truffles + Lion’s Mane + Niacin
  • Friday: Rest (Lion’s Mane)
  • Saturday: Rest (Lion’s Mane)
  • Sunday: Rest (Lion’s Mane)

Repeat this cycle for a maximum of one month, always starting on Monday. After completing one month, take a break of two to four weeks before resuming the protocol.

Benefits of The Paul Stamets Micro dosing Stack

The Stamets Stack, which combines psilocybin, Lion’s Mane mushroom, and niacin, is believed to offer several benefits for cognitive function and neurological growth. While the stack’s safety has not been confirmed through clinical trials, the individual components are generally considered safe when taken in recommended doses.

The 11 potential benefits of the Stamets Stack, as described by Paul Stamets, include:

  1. Promotion of neurogenesis: The stack may support the growth of new neurons in the brain.
  2. Reduced anxiety and depression: Users may experience a decrease in feelings of anxiety and depression.
  3. Improved memory and cognition: The stack has the potential to enhance memory and cognitive abilities.
  4. Improved motor skills: Users may notice improvements in motor skills and coordination.
  5. Stabilized mood: The stack may help in achieving a more stable and balanced mood.
  6. Enhanced creativity: Users may experience an increase in creative thinking and problem-solving abilities.
  7. Improved hearing and vision: The stack may contribute to better auditory and visual perception.
  8. Greater sense of interconnection: Users may feel a stronger sense of connection with others and the world around them.
  9. Relief from PTSD symptoms: The stack may provide relief from symptoms associated with Post Traumatic Stress Disorder (PTSD).
  10. Reduced incidence of neuropathy: The stack may help reduce the occurrence of neuropathic symptoms.
  11. Increased ability to socialize, empathize, and feel courageous: Users may experience improvements in social interactions, empathy, and courage.
  12. Enhanced self-awareness: The stack may promote a deeper sense of self-awareness.

Overall, the Stamets Stack is designed as a nootropic protocol to enhance brain function and encourage novel and adaptive thinking. It is suggested that these effects can potentially contribute to the evolution of human consciousness.

It is important to note that the safety of the stack as a whole has not been confirmed through clinical trials. Therefore, individuals should proceed with caution, follow recommended dosages, and consult with a healthcare professional before considering the use of the Stamets Stack or any other supplementation regimen.

Important Considerations

Before starting the Paul Stamets Stack, consider the following:

  1. Allergic reactions and interactions: Niacin can cause allergies and interact with alcohol and certain medications. Consult a healthcare provider if you have concerns or pre-existing health conditions.
  2. Pre-existing health conditions: Niacin is not recommended for individuals with liver disease, kidney disease, diabetes, gout, or peptic ulcer disease. Seek medical advice before using the stack if you have these conditions.
  3. Limited research in specific populations: There is a lack of comprehensive studies on niacin use in pregnant women, lactating mothers, seniors, and children.
  4. Recommended microdosing protocol: Follow a four-day on, three-day off cycle to prevent tolerance to psilocybin. Take a break of two to four weeks after a four-week cycle.
  5. Flushing effects of niacin: Gradually increase the dose to reduce flushing effects, which include temporary skin redness, tingling, and itching. Stick to regular niacin, as the no-flush variety may not be effective within the Stamets Stack protocol.
  6. Legal considerations: Psilocybin is illegal in many countries. Be aware of the legal status in your jurisdiction before obtaining or using psilocybin.
  7. Mushroom sourcing: Obtain psilocybin mushrooms from a trusted source to avoid consuming the wrong type of mushroom, as many can look alike and be poisonous.
Benefits of The Paul Stamets Micro dosing Stack

When do you need to take a break?

It is recommended to take a break after completing a four-week cycle. After the four-week cycle, it is advised to take a break of two to four weeks before restarting the microdosing process.

This break period allows for the avoidance of building tolerance to psilocybin, the primary compound being microdosed. Taking regular breaks helps to maintain the effectiveness of the protocol and prevents diminishing effects over time.

It also allows the body and mind to readjust and ensures a balanced and sustainable approach to microdosing. Taking breaks and listening to your body’s response is essential to responsible microdosing and allows for a more personalized and optimized experience.

Final Thoughts

In conclusion, Paul Stamets’ microdosing protocol uniquely uses psilocybin mushrooms, Lion’s Mane, and niacin to their full potential. Even though there hasn’t been a lot of research on the safety and effectiveness of this stack, it has become popular because it may boost neurogenesis, reduce anxiety and depression, and improve cognition and creativity.

Before trying this protocol, you should talk to a microdosing coach because each person’s health and possible risks need to be taken into account.

Overall, it’s important to make responsible and well-informed decisions and put safety first when looking into alternative ways to improve mental health and cognitive function.

Author Microdosify

By Rachel Grey

I’m Rachel Grey, a Ph.D. psychologist specializing in psychedelic therapy with psilocybin and natural plant medicines. I obtained my doctorate from the University of Toronto, where I immersed myself in the study of these transformative therapies. With over 10 years of experience, let’s embark on transformative journeys of healing, growth, and self-discovery as we explore the power of psychedelic therapy together.

Updated on November 20, 2022