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Stamets Stack: Microdosing Protocol

This popular combination of supplements, including Psilocybin, Lion’s Mane, and Niacin, is designed to enhance focus, productivity, and overall brain health.

In this article, we will look into the components of the Stamets Stack, how it works, its benefits, and how you can incorporate it into your daily routine.

We will explore the concept of microdosing and the support provided by the community at Microdosify.

Key Takeaways:

  • The Stamets Stack is a combination of natural supplements, including Psilocybin, Lion’s Mane, and Niacin, to support brain health and cognitive function.
  • Paul Stamets is the founder of the Stamets Stack and a renowned mycologist and advocate for the use of psychedelics for mental health.
  • The components of the Stamets Stack work together to promote neuroplasticity, nerve growth, and increased blood flow in the brain.

What is the Stamets Stack?

What is the Stamets Stack?
The Stamets Stack is a blend of natural supplements, including Psilocybin, Lion’s Mane, and Niacin, designed to support brain health, enhance cognitive function, and improve focus.

Psilocybin, known for its potential to promote neurogenesis, enhances neuronal growth and repair in the brain.

Lion’s Mane, a powerful mushroom extract, is known for its ability to stimulate nerve growth factor production, supporting overall brain health and cognitive function.

Niacin, a form of vitamin B3, plays a crucial role in energy metabolism and neurotransmitter synthesis, contributing to improved focus and mood regulation.

When combined, these supplements work togheter to create a comprehensive approach to enhancing brain function, promoting neuroplasticity, and supporting mental well-being.

Who is Paul Stamets?

Paul Stamets is a renowned mycologist known for his extensive research on mushrooms and fungi, particularly their medicinal properties and potential to support brain health.

With a background in mycology and a passion for the natural world, Stamets has dedicated his career to studying the intricate ecosystem of fungi.

His groundbreaking research has led to significant discoveries in the field, shedding light on the therapeutic benefits of mushrooms.

One of his major contributions is the development of the famous Stamets Stack, a combination of different mushroom species aimed at improving overall health and cognitive function.

Stamets’ scientific exploration extends to the neurogenic benefits of mushrooms, emphasizing their potential to stimulate brain cell growth and support mental well-being.

Through his work, Stamets has played a crucial role in making known the use of mushrooms for their health-promoting properties.

What are the Components of the Stamets Stack?

The Stamets Stack consists of three primary components: Psilocybin, Lion’s Mane, and Niacin, each contributing unique benefits to brain health and cognitive function.


Psilocybin, a naturally occurring compound found in certain mushrooms, interacts with serotonin receptors to provide a cognitive boost and enhance mood regulation.

Research suggests that Psilocybin has a profound impact on neurogenesis, the process of generating new neurons in the brain, potentially leading to improved brain plasticity and cognitive function.

By stimulating the growth of new nerve cells and fostering neural connections, Psilocybin may play a pivotal role in enhancing learning, memory, and overall cognitive performance.

Psilocybin has demonstrated promising results in the realm of mental health.

Studies have shown that it can effectively alleviate symptoms of depression, anxiety, and PTSD by altering the brain’s neurochemical balance and promoting emotional resilience.

Lion’s Mane

Lion’s Mane is a potent mushroom known for stimulating neurogenesis and enhancing the synthesis of Nerve Growth Factor (NGF), which supports brain healing and cognitive clarity.

One of the key benefits of Lion’s Mane is its role in promoting NGF synthesis, which is crucial for the growth, maintenance, and survival of nerve cells in the brain.

By increasing NGF levels, Lion’s Mane helps support neuroplasticity, which is the brain’s ability to adapt and reorganize itself. This ability is essential for learning, memory, and overall cognitive function.

Additionally, Lion’s Mane has shown promise in aiding the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Its rich source of bioactive compounds helps protect nerve cells from damage and may slow down the progression of these debilitating conditions.

One convenient way to harness the benefits of Lion’s Mane is through its extract, which concentrates the mushroom’s beneficial compounds for easier consumption and increased effectiveness.


Niacin, also known as Vitamin B3, plays a crucial role in vasodilation, which enhances blood flow to the brain and supports cognitive functions.

When included in the Stamets Stack, niacin acts as a powerful vasodilator, facilitating improved circulation in the brain and boosting mental clarity. This essential nutrient aids in the production of neurotransmitters, contributing to enhanced cognitive processes and memory retention.

Niacin’s collaboration with Psilocybin and Lion’s Mane in the stack creates a synergistic effect, amplifying their individual benefits.

The combination promotes neurogenesis, leading to cell rejuvenation and increased plasticity in the brain.

How Does the Stamets Stack Work?

The Stamets Stack works by harnessing the combined effects of its components to enhance brain functions, stimulate neurogenesis, and support neurotrophic pathways, leading to improved cognitive health.

Psilocybin and Neuroplasticity

Psilocybin plays a significant role in promoting neuroplasticity by enhancing synaptic plasticity and improving overall brain functions.

The mechanism through which Psilocybin exerts its neuroplasticity-promoting effects involves interacting with the serotonin receptors in the brain, particularly the 5-HT2A receptors, leading to increased synaptogenesis and dendritic growth.

This enhanced neural connectivity is crucial for optimizing learning, memory, and overall cognitive functions.

Psilocybin has been found to modulate the default mode network (DMN) in the brain, disrupting rigid thought patterns and allowing for novel connections to be formed. This ability to break free from entrenched neural pathways can be transformative in terms of personal growth and mental flexibility.

Lion’s Mane and Nerve Growth Factor (NGF)

Lion’s Mane enhances the production of Nerve Growth Factor (NGF), which is crucial for neurogenesis and the maintenance of the myelin sheath.

NGF plays a key role in promoting the growth, maintenance, and survival of nerve cells in the brain. With higher levels of NGF, the brain is better equipped to create new neural connections and protect existing ones.

Lion’s Mane, through its unique properties, stimulates the biosynthesis of NGF, providing a natural boost to this vital protein. By supporting NGF production, Lion’s Mane contributes to enhanced neuroplasticity, the brain’s ability to adapt and rewire in response to new experiences and challenges.

Niacin and Blood Flow

Niacin aids in improving blood flow through vasodilation, which is essential for cognitive enhancement and overall brain health.

By increasing blood flow, niacin enhances the delivery of oxygen and nutrients to the brain, supporting optimal cognitive function and mental clarity.

This improved circulation also plays a vital role in reducing inflammation and oxidative stress, which are crucial factors in maintaining brain health.

When combined with Psilocybin and Lion’s Mane, Niacin’s effects on vasodilation are further amplified.

Psilocybin, known for its potential to enhance creativity and problem-solving skills, complements Niacin’s cognitive benefits, while Lion’s Mane, a powerful nootropic, works synergistically to support neurogenesis and overall brain function.

What are the Benefits of the Stamets Stack?

What are the Benefits of the Stamets Stack?
The Stamets Stack offers numerous benefits, including improved cognitive function, enhanced focus and productivity, and increased brain health and neuroprotection.

Improved Cognitive Function

Improved cognitive function is one of the primary benefits of the Stamets Stack, thanks to its ability to enhance neuroplasticity and promote brain rejuvenation.

The various components of the Stamets Stack, such as Lion’s Mane, Niacin, and Psilocybin, work synergistically to support brain health and cognitive performance.

Lion’s Mane mushroom is known for its ability to stimulate the production of nerve growth factor, which plays a crucial role in neuroplasticity and learning. Niacin, a form of vitamin B3, helps improve overall brain function by supporting energy metabolism in the brain cells.

Enhanced Focus and Productivity

The Stamets Stack is known for enhancing focus and productivity by boosting cognitive clarity and optimizing neurotransmitter function.

In terms of cognitive clarity, the Stamets Stack works by reducing brain fog and enhancing mental sharpness. By modulating neurotransmitter levels, this stack helps in maintaining a balanced state that is conducive to improved focus and attention to detail.

Specifically, the components of the stack target dopamine and serotonin receptors, which play a crucial role in regulating mood and cognition.

The synergistic effects of the different mushrooms in the Stamets Stack create a powerful blend that not only sharpens cognitive function but also supports overall brain health.

This combination of benefits makes it a popular choice for individuals looking to optimize their mental performance and achieve peak productivity.

Increased Brain Health and Neuroprotection

The Stamets Stack increases brain health and offers neuroprotection by providing antioxidants that help combat neurotoxin damage.

Antioxidants play a crucial role in maintaining optimal brain function and protecting neural cells from oxidative stress. By scavenging harmful free radicals, these compounds prevent cellular damage and inflammation in the brain, ultimately promoting cognitive longevity.

The unique blend of antioxidants in the Stamets Stack not only shields the brain from neurotoxin-induced harm but also supports the body’s natural defense mechanisms against age-related cognitive decline.

How to Use the Stamets Stack?

Using the Stamets Stack involves following specific instructions and dosage guidelines to ensure optimal benefits from the supplements.

Dosage Guidelines

Dosage Guidelines
The dosage guidelines for the Stamets Stack are typically based on a microdosing protocol to achieve optimal benefits without any adverse effects.

For the Lion’s Mane component of the stack, a typical recommended dosage is around 500-1000mg per day.

This can be taken in the morning to benefit from its cognitive-boosting properties throughout the day.

In terms of Psilocybin mushrooms, a lower dose is usually favored, with starting doses as low as 50mg every few days to avoid any overwhelming effects.

Niacin is usually included in small doses, around 10-20mg, to support the metabolism of Psilocybin. Consistency is key with the Stamets Stack, as sticking to the recommended dosages and schedule ensures gradual improvements over time

Safety Precautions

When using the Stamets Stack, it is essential to follow safety precautions to avoid potential side effects and ensure the safe use of the supplements.

The Stamets Stack is a combination of various mushroom supplements created by mycologist Paul Stamets. While these supplements are generally considered safe, it is important to be aware of possible side effects that may arise, such as digestive issues or allergic reactions.

To mitigate these risks, it is recommended to start with small doses and gradually increase as tolerated.

Consulting a professional before incorporating the Stamets Stack into your routine is crucial, especially if you have any underlying health conditions or are taking medications that may interact with the supplements.

What is the Microdosing Journey?

The microdosing journey involves taking small, sub-perceptual doses of substances like Psilocybin to achieve brain health and cognitive enhancement, supported by communities like Microdosify.

What is Microdosing?

Microdosing involves taking small, sub-perceptual doses of substances like Psilocybin to enhance cognitive functions and overall well-being.

Originating in the realm of psychedelic research, microdosing has gained popularity as a method for individuals seeking to tap into the potential benefits of substances like Psilocybin without experiencing the intense psychedelic effects associated with larger doses.

Some proponents believe that by taking tiny amounts of these substances, individuals can experience heightened creativity, focus, and emotional well-being. This differs from regular dosing practices, where larger doses are consumed for profound psychoactive effects.

The specific cognitive benefits associated with microdosing can include improved mood, increased energy levels, enhanced creativity, and heightened focus.

The rationale behind taking small doses is rooted in the belief that it can subtly alter brain function without causing drastic changes in perception.

This approach is often employed to integrate the potential benefits of substances like Psilocybin into daily life, aiming for sustained enhancements rather than profound alterations in consciousness.

Benefits of Microdosing

The benefits of microdosing include cognitive enhancement, improved mood regulation, and increased creativity, making it a popular practice among many individuals.

Microdosing has shown promising results in improving cognitive functions such as focus, memory retention, and problem-solving abilities. Research suggests that small doses of psychedelics like LSD or psilocybin can enhance brain connectivity and neuroplasticity, leading to heightened mental acuity.

In terms of mental health, microdosing has been linked to reduced symptoms of anxiety, depression, and PTSD. Some users report feeling more emotionally balanced and resilient after incorporating microdosing into their routine.

While more extensive clinical trials are needed, anecdotal evidence from users emphasizes the potential of microdosing to unlock creative thinking and facilitate out-of-the-box problem-solving. Many individuals find that microdosing allows them to tap into their inner creativity and approach tasks with a fresh perspective.

Community Support from Microdosify

Microdosify offers valuable community support for individuals on the microdosing journey, providing guidance, resources, and shared experiences.

Engaging with Microdosify enables those exploring microdosing to connect with like-minded individuals who share similar interests in harnessing the potential benefits of this practice.

The platform acts as a hub for exchanging knowledge, discussing personal stories, and fostering a sense of belonging among participants.

Through active participation in the community, users can access a plethora of information on dosage protocols, effects, and potential risks, all while feeling part of a community that understands and appreciates their journey.

Frequently Asked Questions

What is the Stamets Stack?

The Stamets Stack is a combination of natural supplements, including Psilocybin, Lion’s Mane, and Niacin, that is believed to support brain health, cognitive function, and focus.

Who created the Stamets Stack?

The Stamets Stack was created by mycologist and entrepreneur Paul Stamets, who is known for his extensive research on the health benefits of mushrooms.

What are the benefits of taking the Stamets Stack?

The Stamets Stack is believed to have several benefits, including improved brain function, increased focus and creativity, and reduced anxiety and depression.

Is the Stamets Stack safe to use?

The ingredients in the Stamets Stack are all natural and generally considered safe for consumption. However, as with any supplement, it is important to consult with a healthcare professional before use.

How do I take the Stamets Stack?

The recommended dosage for the Stamets Stack is 1 gram of Psilocybin, 1 gram of Lion’s Mane, and 100mg of Niacin, taken together on an empty stomach. However, it is important to start with small doses and adjust as needed.

Is the Stamets Stack legal?

Psilocybin, one of the main ingredients in the Stamets Stack, is a controlled substance in most countries. Therefore, it is important to check your local laws and regulations before purchasing or using the Stamets Stack.

Author Microdosify

By Rachel Grey

I’m Rachel Grey, a Ph.D. psychologist specializing in psychedelic therapy with psilocybin and natural plant medicines. I obtained my doctorate from the University of Toronto, where I immersed myself in the study of these transformative therapies. With over 10 years of experience, let’s embark on transformative journeys of healing, growth, and self-discovery as we explore the power of psychedelic therapy together.

Updated on July 9, 2024