Microdosing psychedelic substances has garnered attention for its potential benefits on mental health and cognition. Proponents believe it can improve mood, creativity, focus, productivity, and empathy. However, skeptics argue that these effects may be due to a placebo effect.
Nevertheless, recent research on microdosers indicates lower levels of depression, anxiety, and stress, particularly among those with mental health concerns. Health and wellness motives were prevalent, especially among females and individuals with mental health issues.
These findings highlight the potential benefits of microdosing, but further research is needed for a comprehensive understanding.
What is microdosing and how does it work?

Microdosing involves taking small, sub-therapeutic doses of psychedelic substances like LSD or psilocybin. This practice, typically 1/5 to 1/20 of a recreational dose, has gained attention for its potential benefits on mental health, creativity, focus, and productivity.
However, due to variations in potency and lack of regulation, precise dosing can be challenging. LSD, for example, is an invisible and tasteless substance taken in liquid form or on paper.
The effects of microdosing have sparked debates, with proponents believing it enhances mood and empathy, while skeptics attribute perceived benefits to placebo effects.
Beyond personal use, microdosing has a scientific application in drug development. It allows the study of cellular responses by administering doses that don’t produce whole-body effects.
This “Phase 0 study” helps determine a drug’s viability for further testing and reduces resources spent on non-viable drugs and animal testing. Pharmaceutical companies have embraced microdosing, and it has received provisional endorsement from regulatory agencies like the European Medicines Agency and the FDA.
Despite its potential, more research is necessary to fully comprehend the effects and applications of microdosing.
Regulations and standardization are lacking, and further exploration is needed to establish its place in therapeutic interventions.
Read more about Psychedelic Therapy here: Psychedelic Therapy for Mental Health
Benefits of microdosing psychedelics
Microdosing offers potential benefits for mental health, including reduced stress, improved mood, and alleviation of symptoms associated with depression, anxiety, and more. A recent study observed greater improvements in mood, mental health, and psychomotor ability among microdosers.
Here, we’ve compiled some of the most frequently mentioned psychological, physiological, and spiritual advantages of microdosing.
Mental Benefits of Microdosing
Microdosing has been associated with a range of mental benefits that can positively impact various aspects of life. By taking small doses of psychedelic substances, individuals have reported improved concentration and focus, allowing them to engage more effortlessly in tasks and achieve a state of flow.
Creativity is often enhanced, leading to innovative thinking and problem-solving capabilities. Productivity tends to increase, accompanied by a heightened overall awareness of one’s surroundings. Microdosing has also been linked to a more balanced mood, improved decision-making abilities, and a positive mindset.
Moreover, individuals have reported a decrease in symptoms of depression, ranging from mild to clinical cases, and a reduction in procrastination tendencies. These mental benefits highlight the potential of microdosing as a tool for enhancing cognitive function and well-being.
Spiritual Benefits of Microdosing

Microdosing has been reported to offer various spiritual benefits, enhancing one’s overall sense of well-being and connection. One notable benefit is increased emotional awareness, allowing individuals to better understand and navigate their own emotions.
Microdosing has also been associated with a greater emotional connection with others, fostering deeper and more meaningful relationships. It can contribute to a heightened sense of presence, enabling individuals to fully engage and appreciate the present moment.
Microdosing has been linked to increased openness, facilitating a more receptive attitude towards new experiences and perspectives. It can evoke a sense of wonder and awe, as individuals perceive the world with renewed curiosity and fascination.
Microdosing has also been reported to foster a sense of belonging and unity, promoting a greater connection with others and the broader world. It may contribute to a deepened connection with spirituality and a clearer understanding of one’s life mission.
Additionally, microdosing can enhance gratitude for life, cultivating a deeper appreciation for the joys and blessings it offers. It is important to note that the spiritual benefits of microdosing are subjective experiences and may vary among individuals.
Physical Benefits of Microdosing
Microdosing has been associated with a range of physical benefits that can contribute to overall well-being. One notable benefit is improved sleep, although further research is needed to understand the specific effects of microdosing on sleep patterns.
Individuals have reported increased physical energy, allowing them to engage in activities with greater vitality. Sensory perception is often enhanced, leading to a heightened appreciation of the surrounding environment.
Microdosing has also been linked to a reduction in premenstrual syndrome (PMS) symptoms and decreased levels of pain. Moreover, some individuals have reported a better connection with their bodies, experiencing improved body awareness and less stuttering.
Additionally, microdosing has shown potential as a supportive tool for quitting smoking and addressing other addictive behaviors.
While these physical benefits are promising, it is important to approach microdosing responsibly and seek professional guidance when needed.
Microdosing and the placebo effect
A comprehensive review of studies on microdosing found consistent findings across variables such as changes in time perception, increased pain tolerance, and mild alterations in conscious state.
Self-report studies indicated improvements in mental health, attentional capacities, personality changes, and general well-being. However, certain variables showed mixed results between self-report and controlled laboratory studies, potentially influenced by dosage levels and duration of microdosing.
While the placebo effect poses challenges in evaluating the true effects of microdosing, the consistent reports from diverse individuals worldwide suggest that it offers more than just placebo responses.
Further research is needed to understand the underlying mechanisms and the influence of placebo responses. By examining subjective experiences and conducting rigorous controlled studies, we can unravel the complexities surrounding microdosing and its interaction with the placebo effect.
While the placebo effect may contribute to some perceived benefits of microdosing, indications exist that the effects extend beyond subjective expectations.
Ongoing exploration of microdosing and its potential benefits will contribute to our understanding of the mind, psychedelics, placebo responses, and personal experiences.
Risks and Side Effects of Microdosing
Risks and side effects of microdosing psychedelics should be carefully considered before engaging in this practice. Here are some of the potential risks and side effects to be aware of:
Physiological Discomfort: Some individuals may experience physiological discomfort on microdose days, including stomachaches, headaches, or fatigue. A small percentage of users may also report insomnia, temperature dysregulation, or other discomforts.
Cardiac Concerns: Long-term use of psilocybin may pose a risk of cardiac valvopathy or valve damage. Further research is needed to understand the potential effects of psilocybin on the heart.
Psychological Effects: A subset of users may experience increased anxiety, reduced energy levels, or impaired focus during microdosing. Feelings of depression, dissociation, cognitive impairment, or migraines have also been reported, although they are relatively rare.
Variation in Dosage and Origin: Psilocybin dosage can vary significantly among different mushrooms and even within the same strain. Inconsistency in dosage may lead to unpredictable effects and challenges in determining the appropriate dose for microdosing. Synthetic versions of psilocybin aim to standardize dosage, but their availability is limited and purity concerns exist.
Legal and Safety Considerations: Psychedelics, including psilocybin, are illegal in many countries. Sourcing and purchasing psychedelics can be challenging, involving unreliable suppliers and potential exposure to impure or harmful substances.
Lack of Research and Long-Term Data: Limited clinical research on microdosing hinders a comprehensive understanding of its long-term effects and potential risks. More studies are needed to assess the safety and potential consequences of extended microdosing practices.
Future of Microdosing for Mental Health Care

The future of mental health care may involve exploring alternative options such as microdosing psychedelics. Depression remains a significant public health burden, with many patients not responding to existing treatments.
While it is still too early to determine the exact efficacy of microdosing, further research is crucial to understand its potential in alleviating the harm caused by mental health disorders. Anecdotal reports and the need for understanding the specific benefits and risks associated with microdosing highlight the importance of future studies.
Continued investigation into psychedelics, both in microdosing and higher doses, holds promise for advancing mental health care and offering new possibilities for treatment.
How to get started with microdosing psychedelic drugs
Microdosing involves practical considerations such as finding the right dose and dosage ranges. It is recommended to start with a slightly higher dose than a microdose to ensure noticeable effects, gradually working towards the lowest effective dose.
Mushrooms typically range from 0.15-0.3g for microdosing and 2-3g for a full trip, while LSD microdoses are around 10-20ug. Different microdosing schedules can be followed, such as Dr. Fadiman’s approach of one microdose every three days or a balanced approach of microdosing every other day. You can also try out Paul Stamet’s Protocol to get started.
It’s important to track the effects of microdosing on various aspects like mental clarity, creativity, emotions, social interactions, body sensations, capabilities, and overall outlook.
By considering these factors, individuals can personalize their microdosing journey and explore its potential benefits.
Final Thoughts
Microdosing psychedelics is a personal decision that should be approached with caution and medical advice. It’s important to consider legality and ensure substance quality. Although long-term benefits and safety are still being studied, growing research suggests positive outcomes.
Remaining informed, following legal guidelines, and approaching microdosing responsibly are crucial. Microdosing holds promise for mental health, creativity, focus, and productivity. By making informed decisions and seeking proper guidance, microdosing may offer new possibilities for personal growth.
As research progresses, further insights and potential benefits may emerge. With careful consideration, microdosing psychedelics can be an avenue for exploring the potential benefits associated with these substances.