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Why Are Canadians Microdosing Mushrooms?

More and more Canadians are microdosing mushrooms to treat their anxiety and depression. Psilocybin has a chemical structure like that of serotonin and works by targeting the 5-HT2A receptors in the brain. This increases the production of Brain Derived Neurotrophic Factor (BDNF) and increases the transmission of Glutamate. Inside our brains are neurons that are involved in emotional and cognitive functions, Brain Derived Neurotrophic Factor are vital in maintaining and growing these neurons in key brain circuits. Those with anxiety and depression are known to have reductions in BDNF which can be treated by using psilocybin to increase BDNF production.

Psilocybin has shown significant improvements in individuals with major depressive disorder, particularly in reducing negative thought patterns and enhancing mood.

Microdosing psilocybin helps alleviate anxiety and depression by causing parts of the brain that don’t normally communicate with each other, to start talking to one another. These new connections allow the brain to decrease the activity in our Default Mode Network (DMN). DMN is responsible for how we think of ourselves, others, and the world around us, and it is also responsible for our memories as well as our thoughts about the future. An over-stimulated DMN can lead to anxiety and depression.

Psilocybin disrupts the activity in our DMN and helps to remove negative thought patterns, allowing users to overcome traumas and experience a natural form of healing.

Microdosing Canada

Optimal Dosage

Research indicates that 25 mg of psilocybin dose for depression, paired with psychological support, can effectively reduce depression symptoms without adverse effects.

Consideration of depression severity, individual sensitivity, and the setting is crucial in determining the right dose.

Microdosing regimens range from microdose to heroic dose, each with specific effects on mood and perception.

Side Effects and Precautions

Potential side effects include nausea, headaches, increased anxiety, and disturbed sleep patterns.

Psilocybin is not recommended for individuals with severe mental health issues, a history of psychosis, cardiovascular issues, pregnant or breastfeeding women, and those with allergies to psilocybin or mushrooms.


In recent years, interest in psychedelics like Psilocybin has been gaining popularity as a form of medicine to treat mental illnesses like OCD and anxiety. Scientists and medical researchers have been conducting tests to better understand the potential medicinal benefits of microdosing psilocybin. Although microdosing psilocybin maybe a viable solution to treat anxiety and depression, it may have adverse effects on some users with pre-existing medical issues. It is highly recommended that you speak with your doctor or other health care professionals prior to using any of our microdosing supplements.